Comparative analysis of treatment efficacy of different methods on multiple segmental adult cervical spinal cord injury without fracture dislocation
10.3760/cma.j.issn.1671-8925.2013.09.017
- VernacularTitle:成人多节段无骨折脱位型颈脊髓损伤不同治疗方法的疗效对比分析
- Author:
Guang-Quan ZHANG
1
;
Ke LIU
;
Yan-Zheng GAO
;
Shu-Lian CHEN
;
Kun GAO
;
Yong-Qiang ZHAO
;
Zong-Yan GAO
Author Information
1. 河南省人民医院骨科
- Keywords:
No fracture dislocation;
Spinal cord injury;
Nerve growth factor;
Operation
- From:
Chinese Journal of Neuromedicine
2013;12(9):940-943
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the treatment effects of operation and nerve growth factor on adult multisegmental cervical spinal cord injury without fracture dislocation.Methods Sixty-eight patients with multiple segmental cervical spinal cord injury without fracture dislocation,admitted to our hospital from January 2004 to May 2011,were chosen in our study; according to the will of the patients,18 patients received conservative treatment (group A),25 patients were treated by posterior single open-door laminoplasty (group B) and the other 25 patients were treated with posterior single open-door laminoplasty combined with nerve growth factor (group C,once daily for 4 weeks); their clinical data were retrospectively analyzed.Follow up was performed at 3,6 and 12 months after the treatments;Japanese Orthopaedic Association (JOA) scale was employed to evaluate the clinical efficacy.Results Three,6,12 months after the treatments,the JOA scale scores were statistically different among the three groups (P＜0.05); the scores in group B and C were significantly higher than those in group A at all time points (P＜0.05); 6 and 12 months after the treatmemts,the JOA scale scores in group C were significantly higher than those in group B (P＜0.05).Conclusion To patients with multisegmental cervical spinal cord injury without fracture dislocation,conservative treatment can make the spinal cord function partially restored,but the effect is limited; exogenous nerve growth factor has good repairing effect on spinal cord injury.
