Magnetic resonance spectroscopy characteristics of prefrontal white matter and lenticular nucleus in patients with bipolar H disorders
10.3760/cma.j.issn.1671-8925.2013.09.014
- VernacularTitle:双相障碍Ⅱ型患者前额叶白质、豆状核磁共振波谱分析
- Author:
Hai-Yan ZHANG
1
;
Zhuang KANG
;
Sheng-Lin WEN
;
Ji-Hui YUE
;
Hong WANG
Author Information
1. 中山大学附属第三医院普通内科
- Keywords:
Bipolar Ⅱ disorder;
Magnetic resonance spectroscopy;
Frontal lobe;
Lenticular nucleus
- From:
Chinese Journal of Neuromedicine
2013;12(9):927-931
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the magnetic resonance spectroscopy characteristics of prefrontal white matter and lenticular nucleus in patients with bipolar Ⅱ disorders.Methods Thirty patients with bipolar Ⅱ disorders and 20 healthy controls,collected in our hospital from September 2012 to April 2013,were evaluated with Multi-Voxel 1H-MRS scans on prefrontal white matter and lenticular nucleus to assess the levels of N-acetyl aspartate (NAA),choline compound (Cho),creatine (Cr) and myo-inositol (mI),and then,the ratios of NAA/Cr,Cho/Cr,mI/Cr,NAA/Cho and NAA/Cho+Cr were calculated.Results Levels ofNAA,NAA/Cr,Cho and mI in the right prefrontal white matter were significantly lower in patient group than those in the normal controls (P＜0.05); NAA level,and ratios of NAA/Cr,NAA/Cho,NAA/Cho+Cr in the left prefrontal white matter were obviously lower in patient group than those in the normal controls (P＜0.05); NAA and Cho in right lenticular nucleus were lower as compared with those in the healthy control subjects (P＜0.05).Conclusion Prefrontal white matter fiber damage and glial cell disfunction occur in patients with bipolar Ⅱ disorder; besides,neuronal loss and disfunction in the right lenticular nucleus exist.
