Correlation between serum neuron specific enolase level and psychological status of patients with cerebral concussion
10.3760/cma.j.issn.1671-8925.2013.08.023
- VernacularTitle:脑震荡患者血清中神经元特异性烯醇化酶与心理状况的相关性研究
- Author:
Peng-Zhou ZHAO
1
;
Jiang-Bing LUO
;
Jing-Lun WU
;
Ying-Xiong OU
;
Ben-Sheng YANG
;
Rui-Tian YU
;
Sheng FANG
Author Information
1. 529051,广东省江门市人民医院神经外科
- Keywords:
Cerebral concussion;
Neuron specific enolase;
Psychological disturbance;
Symptom check-List 90
- From:
Chinese Journal of Neuromedicine
2013;12(8):849-851
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between the changes of serum neuron specific enolase (NSE) level and psychological statuses in patients with cerebral concussion.Methods Forty patients with cerebral concussion,admitted to our hospital from January 2012 to December 2012,were chosen in our study as experimental group,and other 40 healthy controls performed physical examination in our Physical Examination Center at the same period were chosen.The serum NSE level in the two groups was determined by enzyme-linked immunosorbent assay (ELISA); Symptom Checklist 90 (SCL-90) scale was performed in 40 patients at different times after injury,and these data were compared with those from the national norm; the correlation between the changes of serum NSE level and SCL-90 scores was analyzed.Results The serum NSE level in the experimental group 1 d after the injury was obviously higher than that in the control group (P＜0.05); 3 and 7 d after the injury,the serum NSE level in the experimental group was close to normal level,which showed no significant differece as compared with that in the control group (P＞0.05).The SCL-90 scores in the experiemtal group 1,3 and 7 d after injury was signficantly higher than that of the national norm (P＜0.05).Positive corelation was noted between serum NSE level and SCL-90 scores 1 and 3 d after injury (r=0.498,P=0.001; r=0.418,P=0.007);however,negative corelation was noted btween the two 7 d after injury (r=0.213,P=0.186).Conclusion Different corelation can be noted between serum NSE level and SCL-90 scores at different time points;combined application of serum NSE level and SCL-90 scores can promote the diagnosis and treatment of patients with brain concussion.
