Mild hypothermia therapy plus edaravone improves neurological outcomes in patients with severe traumatic brain injury
10.3760/cma.j.issn.1671-8925.2013.08.014
- VernacularTitle:轻度低温联合依达拉奉治疗提高重型颅脑损伤疗效
- Author:
Lu-Qiu ZHOU
1
;
Zhen MA
;
Zhi-Song JIU
;
Wen-Long KONG
;
Guo-Chang CHEN
;
Xiao-Feng SHI
Author Information
1. 518116,深圳市龙岗中心医院神经外科
- Keywords:
Traumatic brain injury;
Mild hypothermia;
Edaravone
- From:
Chinese Journal of Neuromedicine
2013;12(8):815-818
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the treatment effect of edaravone plus mild hypothermia treatment on patients with acute severe traumatic brain injury (TBI).Methods One hundred and forty-three patients with TBI,admitted to our hospital from February 2008 to September 2012,were randomly divided into 4 groups:control group (group A,routine treatment,n=35),mild hypothermia treatment group (group B,routine treatment plus temperature control at the range of33～34 ℃ for 2-14 days,n=36),edaravone treatment group (group C,routine treatment plus edaravone up to 14 days,30 mg per time,twice per day,n=36) and mild hypothermia plus edaravone treatment group (group D,routine treatment combined with mild hypothermia plus edaravone n=36).Intracranial pressure (ICP) and arterial blood glucose were determined at admission,and 24 and 72 h after admission; Glasgow Outcome Scale (GOS) scores were assessed 3 months after the treatment.Results At 24 and 72 h after admission,the mean ICP of group B and group C was significantly lower than that of group A (P＜0.05); that of group D was significantly lower than that of group B and group C (P＜0.05).The mean blood glucose of group B and group C was obviously lower than that of group A (P＜0.05); group D was obviously lower than group B and group C (P＜0.05).The rate of good neurologic function (GOS scores 4-5) in group D was better than that of group B and group C (P＜0.05),which was significantly better than that of group A (P＜0.05).Conclusion It is much more effective to use mild hypothermia plus edaravone treatment than simple mild hypothermia or edaravone treatment in the early treatment of acute severe TBI.
