Effect of epileptic seizure on intelligence of patients with tuberous sclerosis complex
10.3760/cma.j.issn.1671-8925.2013.08.007
- VernacularTitle:结节性硬化症患者癫痫发作对智力的影响
- Author:
Hua LI
1
;
Xiang-Shu HU
;
Ling-Xia FEI
;
Ding-Lie SHEN
;
Su-Yue PAN
Author Information
1. 广东三九脑科医院
- Keywords:
Tuberous sclerosis complex;
Epilepsy;
Mental retardation
- From:
Chinese Journal of Neuromedicine
2013;12(8):787-789
- CountryChina
- Language:Chinese
-
Abstract:
Objective To reveal the relationships between epileptic seizure in patients with tuberous sclerosis complex (TSC) and their intelligence.Methods A retrospective analysis was performed on the clinical data of 110 patients with seizure secondary to TSC,admitted to our hospitals from May 2007 to May 2012; the prognostic factors for mental retardation were analyzed.Results There were 67 males and 43 females in the TSC patients with seizures.The age of seizure onset ranged from 10 days to 28 years; the onset age was less than 1 year in 30％ and less than 3 years in 65％ of TSC patients.Twelve patients presented epileptic spasms; 40 had normal intelligence and 51 had mental retardation.In patients having onset age younger than 1 year,80％ had mental retardation; 92％ patients with epileptic spasms had mental retardation; 65％ patients with two seizure patterns had mental retardation; 62％ TSC patients with seizure frequency exceeding 4 times per month and 63％ patients with seizure history exceeding 5 years both had mental retardation.Conclusion The patients with seizure onset age less than 1 year old and having a history of epileptic spasms are more prone to mental retardation; so early control of seizure should be done to improve the intelligence.
