Correlation between serum anti-ganglioside M1 antibodies levels and severities of childhood autism
10.3760/cma.j.issn.1671-8925.2013.07.018
- VernacularTitle:血清抗神经节苷脂M1抗体水平与儿童孤独症严重程度的相关性研究
- Author:
Jing ZHANG
1
;
Yan-Qun CHANG
;
Yan-Zhu JIANG
;
Rong-Hua ZHANG
Author Information
1. 广州医学院研究生院
- Keywords:
Anti-ganglioside M1 antibodies;
Childhood autism;
Autoimmunity
- From:
Chinese Journal of Neuromedicine
2013;12(7):723-727
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of serum anti-ganglioside M1 antibodies levels in childhren with autism,explore its relation of with severities of childhood autism to provide clue and evidence for pathogenesis and treatment of children with autism.Methods Fifty children with autism,received training in our special training institution from June 2012 to August 2012,were chosen in our study; another 50 healthy children,collected in our hospital at the same period,were used as control group.The serum anti-ganglioside M1 antibodies levels were detected by using enzyme-linked immunosorbent assay (ELISA).The severities of autism were assessed by childhood autism rating scale (CARS).The serum anti-ganglioside M1 antibodies levels were compared between the two groups,between different severities of childhood autism and between geder,and then,corelation analysis was performed.Results According to the highest cut-off value of serum anti-ganglioside M1 antibodies,increased serum levels of anti-ganglioside M1 antibodies were found in 24％ (12/50) of all autistic children and 4％ (2/50) of normal children,with significant difference (P＜0.05); 7.7％ (2/26) of children with mild to moderate autism and 41.7％ (10/24) of children with severe autism had increased serum levels of anti-ganglioside M1 antibodies,with significant difference between the two groups (P＜0.05).The serum anti-ganglioside M1 antibody level of children with autism [12.79 (146.02) ng/mL] was obviously higher than that of the healthy controls [11.35 (53.80) ng/mL] with statistically significant difference (P＜0.05).The anti-ganglioside M1 antibody level of the female autistic children [191.74 (216.18) ng/mL] was obviously higher than that of the male autistic children [11.11 (9.51) ng/mL] with statistically significant difference (P＜0.05).Correlation analysis showed that the serum level of anti-GM1 antibodies of autistic children had significantly positive correlation with CARS scores (r=0.866,P＜0.005).Conclusion The serum anti-ganglioside M1 antibodies level may be a biochemical sign of autism and is associated with the severity of childhood autism.
