ATP-binding cassette subfamily B member 1 transporter gene C3435T polymorphisms and resistance to antiepileptic drugs in epilepsy: a Meta analysis
10.3760/cma.j.issn.1671-8925.2013.07.009
- VernacularTitle:ABCB1基因C3435T多态性与癫痫耐药关系的Meta分析
- Author:
Jing-Jing SHI
1
;
Xiao-Lei LI
;
Feng YU
;
Yong ZHANG
;
Qing-Chuan LIAO
Author Information
1. 南通体臣卫生学校药学医技系
- Keywords:
Epilepsy;
ATP-binding cassette subfamily B member 1 transporter gene;
Pharmacoresistance;
Meta-analysis
- From:
Chinese Journal of Neuromedicine
2013;12(7):685-690
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the relation of ATP-binding cassette subfamily B member 1 (ABCB1) transporter gene C3435T polymorphisms and resistance to antiepileptic drugs (AEDs) in epilepsy by conducting a Meta-analysis.Methods Electronic search strategy was carried out among the databases from home and abroad to collect qualified research papers according to the inclusion and exclusion criteria.Studies with a case-control design involving the association of ABCB1 C3435T polymorphisms and resistance to AEDs were collected and analyzed by alleles (C vs T) and genotypes with co-dominant (CC vs TT and CT vs TT),dominant (CC+CT vs TT),and recessive (CC vs CT+TT) models in overall and in ethnicity subgroups.Results A total of 23 association studies including 7864 patients (3704 drug-resistant patients and 4160 drag-responsive patients) were pooled in this Meta-analysis.The allelic association of ABCB1 C3435T with risk of resistance to AEDs was not significant under random-effects model (OR=1.05,95％CI:0.94-1.18,P=0.390) in overall analyses.Similar results were also obtained for all genetic models in the stratified analyses by ethnicity subgroups.There was no publication bias.Conclusion The polymophisms of ABCB1 C3435T may not involve in risk of resistance to AEDs in epilepsy.
