Clinical significance of matrix metalloproteinases-9 content in cerebrospinal fluid of brain injury

VernacularTitle:脑损伤后脑脊液中基质金属蛋白酶-9的临床意义研究
Author: Hui-Tian YU ¹ ; Hua-Wei YE ; Rong-Kang MAI ; Xian-Fu JIANG ; Yu SONG ; Ju-Fang LAI ; Xiao-Jun SHI
Author Information

1. 5108100,深圳市宝安区人民医院神经外科
Keywords: Brain injury; Cerebrospinal fluid; Matrix Metalloproteinases-9
From: Chinese Journal of Neuromedicine 2013;12(6):636-638
CountryChina
Language:Chinese
Abstract: Objective To investigate the changes of matrix Metalloproteinases-9 (MMP-9) content in the cerebrospinal fluid of patients with brain injury and its clinical significance.Methods Sixty cerebrospinal fluid (CSF) specimens from patients with traumatic brain injury were chosen in our study as experimental group,and other CSF samples from 35 healthy subjects were selected as control group.The content of MMP-9 in cerebrospinal fluid was measured by enzyme-linked immunosorbent assay (ELISA) at 24 h and 72 h,1 and 2 weeks,respectively; and the comparative study was performed.Results The MMP-9 content in all CSF samples from the experimental group was significantly higher than that in the healthy control group (P＜0.05).Conclusion MMP-9 content in CSF of patients with brain injury increases obviously; MMP-9 in CSF may contribute to the severity of traumatic brain injury determination and guide the treatment strategies,which is worth for further study.