Expression of Aurora-A in gliomas and its clinical significance
10.3760/cma.j.issn.1671-8925.2013.04.013
- VernacularTitle:脑胶质瘤Aurora-A的表达及其临床意义
- Author:
Wan-Chun YIN
1
;
Zhong-En GAO
;
Li-Ji PENG
;
Rong-Liang FENG
;
Hai-Bin LI
;
Zhi-Dong YAN
;
Qing-Jun CEN
Author Information
1. 526021,肇庆市第一人民医院院神经外科
- Keywords:
Glioma;
Aurora-A;
Prognosis
- From:
Chinese Journal of Neuromedicine
2013;12(4):386-388
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of Aurora-A in gliomas and its relationship with clinical significance of gliomas.Methods Forty glioma specimens kept with paraffin,including 8 with WHO grade Ⅰ,8 with WHO grade Ⅱ,10 with grade Ⅲ and 14 with grade Ⅳ,collected in our hospital from June 2010 to August 2012 during the surgery,were chosen in our study.The expression of Aurora-A was detected by immunohistochemistry in these 40 glioma specimens.The relationships between Aurora-A expression and clinical factors were analyzed.Results The Aurora-A protein expression mainly located in the cytoplasm and (or) nucleus; positive expression rate of Aurora-A was 72.5％ (29/40); the Aurora-A protein expression was significantly different in the glioma specimens of different pathological grades and different survival times of the patients:Aurora-A protein expression was positively related with pathological grades,and the Aurora-A protein expression in patients having survival time shorter than or equal to 3 years was significantly higher than that in patients having survival time longer than 3 years (P＜0.05).Conclusion Over-expression of Aurora-A in gliomas is correlated with prognosis of patients; Aurora-A maybe a potential marker for gliomas and a new therapy target.
