Programming analysis of subthalamic nucleus deep brain stimulation
10.3760/cma.j.issn.1671-8925.2013.03.018
- VernacularTitle:丘脑底核脑深部电刺激术后程控分析
- Author:
Wei SHEN
1
;
Kun YANG
;
Sheng-Xue HE
;
Zhong-Run QIAN
;
Zhen-Guo SUN
;
Jun XU
;
Wen-Bin ZHANG
Author Information
1. 南京医科大学附属脑科医院神经内科
- Keywords:
Parkinson's disease;
Subthalamic nucleus;
Deep brain stimulation
- From:
Chinese Journal of Neuromedicine
2013;12(3):293-295
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analysis the effect of subthalamic nucleus deep brain stimulation (STN-DBS) on Parkinson's disease (PD) and the regulatory strategies of these stimulation parameters.Methods Six patients with PD,admitted to and received STN-DBS in our hospital from February 2012 to December 2012,were chosen in our study; the clinical symptoms of all patients were evaluated by Unified Parkinson's Disease Rating Scale (UPDRS) before and 1 mouth after STN-DBS operation;stimulation parameters were also recorded.Results The UPDRS Ⅰ scores of these patients were not significantly different between before and 1 month after STN-DBS (P＞0.05).As compared with those before surgery,the UPDRS Ⅱ,Ⅲ and Ⅳ scores of these patients 1 month after STN-DBS were significantly decreased (P＜0.05).All patients received unipolar stimulation with stimulus frequencies of equal to or greater than 130 Hz,stimulus voltages of 1.97±0.23 V and stimulus pulses of 90-120 μs.Follow-up was performed for 2～8 months,showing stable symptoms and no stimulation-related complications in all the patients.Conclusion STN-DBS could significantly improve the motor function and living quality on medium-late term PD patients; under high-frequency stimulation,the voltage and pulse width could be programmed by the energy per pulse (V· μs) value.
