Meta-analysis of association between cytochrome P450 4F2 V433M polymorphisms and susceptibility of ischemic stroke
10.3760/cma.j.issn.1671-8925.2013.02.012
- VernacularTitle:细胞色素P450 4F2 V433M位点基因多态性与缺血性脑卒中易感性的meta分析
- Author:
Wei WEI
1
;
Xin CHEN
;
Zong-Ze GUO
Author Information
1. 中国医科大学附属第一医院神经外科
- Keywords:
Ischemic stroke;
Cytochrome P450 4F2 V433M;
Polymorphism;
Susceptibility;
Meta-analysis
- From:
Chinese Journal of Neuromedicine
2013;12(2):161-165
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between cytochrome P450 4F2 (CYP4F2)V433M polymorphisms and susceptibility of ischemic stroke (IS) by means of meta-analysis to provide evidence for genetic etiology.Methods The case-control studies on association of CYP4F2 V433M polymorphisms and IS were retrieved in large databases from home and abroad.The software stata 11.0was used for meta-analysis.According to the results of heterogeneity test,we selected fixed or random effect model to calculate the combined odd ratio and 95％ confidence interval (95％ CI),and the publication bias was assessed by Egger's and Begg's test.Results Five eligible literatures and 6 populations were included.Recessive model (VV vs.VM +MM) was selected as the best genetic model.(1) Statistics of the combined data showed that as compared with that in patients with wild type VV,correlation of polymorphisms and IS in patients with heterozygosis type (VM) and homozygotic type (MM) was not significant (OR=1.11,95％CI:0.91-1.34,P=0.304).(2) Subgroup analysis showed that the combined OR of susceptibility to IS in VM+MM compared to VV wild homozygotes was 1.37 in male,with significant difference (95％CI:1.16-1.60,P=0.000),but no significance in female (P＞0.05); no significant difference on OR of studies involving V433M was noted between Asian and Caucasoid (P＞0.05); in people older than 60 years,V433M polymorphism could increase the risk of IS (OR=1.2,95％CI:1.01-1.42,P=0.039),but no significant difference in people ＜60 years (P＞0.05).Conclusion CYP4F2 V433M maybe the susceptible gene of IS in male and people older than 60 years.
