Relationship between vascular endothelial growth factor level and both cerebral artery stenosis and collateral circulation formation in patients with transient carotid artery ischemic attack
10.3760/cma.j.issn.1671-8925.2013.02.008
- VernacularTitle:颈动脉系统TIA患者血管内皮生长因子水平与脑动脉粥样硬化狭窄及侧支循环形成的关系
- Author:
Zhi-Min TANG
1
;
Fang LING
Author Information
1. 430050,武汉市第五医院神经内科
- Keywords:
Vascular endothelial growth factor;
Transient ischemic attack;
Cerebral artery stenosis;
Collateral circulation
- From:
Chinese Journal of Neuromedicine
2013;12(2):141-146
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the level of serum vascular endothelial growth factor (VEGF) and both cerebral artery stenosis and coronary collateral formation in patients with transient carotid artery ischemic attack (TIA).Methods Ninety patients with TIA,admitted to our hospital from January 2007 to December 2010,were chosen in our study.The plasma VEGF level was determined by enzyme-linked immunosorbent assay (ELISA).The location,degree of stenosis and patterns of collateral circulation were examined by digital subtraction angiography (DSA),and the relationships between the level of plasma VEGF and both cerebral artery stenosis and coronary collateral circulation were assessed.Results The VEGF level in patients with cerebral artery stenoses (n=66,[292.65±131.04 ng/L]) increased as compared with that in controls with normal cerebral artery (n=24,[82.83±45.47 ng/L]) with significant difference (P＜0.05).In the 66 patients with cerebral artery stenoses,mild stenosis was noted in 7 (10.7％),moderate stenosis in 15 (22.7％),severe stenosis in 35 (53.0％) and occlusion in 9 (13.7％).When the degree of cerebral artery stenosis became severer,the VEGF level was higher,enjoying positive correlation with the degree of stenosis (r=0.759,P=0.000).No collateral circulation appeared in 7 patients; collateral circulations were formatted in 46 patients with TIA,including anterior communicating compensation (n=11,23.9％),posterior communicating compensation (n=9,19.6％),leptomeningeal anastomosis compensation (n=5,10.9％),extemal carotid artery compensation (n=3,6.5％) and joint compensations (n=18,39.1％); the VEGF level in patients with joint compensations ([388.06±91.27] ng/L) was higher than that in patients with single type of collateral circulation ([303.25±121.65] ng/L,P＜0.05); that in patients with single type of collateral circulation was higher than that in patients without collateral circulation ([177.43±87.87] ng/L,P＜0.05).Conclusion VEGF might enhance the collateral circulation formation and doubly regulate the development of atherosclerosis.
