Interleukin-1α and interleukin-6 expressions in craniopharyngiomas
10.3760/cma.j.issn.1671-8925.2013.02.005
- VernacularTitle:IL-1α、IL-6在颅咽管瘤组织中表达的研究
- Author:
Ning-Ning ZHANG
1
;
Yi-Peng ZHENG
;
Kun CHEN
;
Yu-Chan HUANG
;
Jia-Ping LIN
Author Information
1. 泰山医学院附属医院神经外科
- Keywords:
Craniopharyngioma;
Interleukin-1α;
Interleukin-6;
Microsurgery
- From:
Chinese Journal of Neuromedicine
2013;12(2):127-130
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlations of interleukin-1α (IL-1α) and IL-6expressions in craniopharyngiomas with the pathological subtypes,removal rate and recurrence rate,and explore their clinical significance.Methods Sixty-nine pathologic specimens ofcraniopharyngiomas,collected in our hospital during the microsurgery from January 2003 to October 2009,were chosen in our study; the craniopharyngiomas were classified into two different pathological subtypes:enamel cells and nipple squamous cells.The IL-1α and IL-6 expressions were detected in craniopharyngioma tissues by immunohistochemistry.The correlations of IL-1α and IL-6 expressions in craniopharyngiomas with the pathological subtypes,removal rate and recurrence rate were analyzed statistically.Results The total tumor removal was achieved in 50 cases (72.5％),subtotal removal in 13 cases (18.8％) and partial removal in 6 cases (8.7％).Nine cases (14.1％) were recurrent during the follow-up.IL-6-positive expression was detected in 28 cases,and IL-1α-positive expression in 3 cases; IL-1α and IL-6 expressions in craniopharyngiomas with different pathological subtypes showed no significant difference (P＞0.05);craniopharyngiomas with postoperative recurrence or without showed no obvious difference (P＞0.05).The difference of IL-1 α expression in patients with total removal,subtotal removal and partial removal showed no statistically significance (P＞0.05); while that of IL-6 expression had significant difference (P＜0.05).Conclusion IL-6 involves in the inflammatory reaction between craniopharyngioma and its surrounding brain tissues,which may be the important influencing factor of total removal of the craniopharyngioma.
