Distribution of blood vessels and relationship of angiogenesis with hypoxia-inducible factor-1α and vascular endothelial growth factor in meningiomas
10.3760/cma.j.issn.1671-8925.2013.01.015
- VernacularTitle:脑膜瘤内的血管分布和血管生成与HIF-1α、VEGF的关系
- Author:
Yong LUO
1
;
Shao-Hua LIN
;
Quan HUANG
Author Information
1. 528400,中山市人民医院神经外科
- Keywords:
Meningioma;
Microvessel density;
Vascular endothelial growth factor;
Hypoxia-inducible factor-1α
- From:
Chinese Journal of Neuromedicine
2013;12(1):68-71
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution of blood vessels and the relationship of angiogenesis with hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in meningiomas.Methods Fifteen specimens of meningiomas,collected in our hospital during the resection and conformed by pathology from May 2010 to March 2011,were chosen; 4 different tissues from each specimen were taken,including the tail sign,base center,tumor' s center and tumor' s margin; three successive slices were made from each tissue part.Envision immunohistochemistry was employed to detect the expressions of CD34,VEGF and HIF-1α and their different distributions were compared.Results CD34 mainly disturbed in the cell membrane and cytoplasm,showing yellow granules in the dyeing; VEGF located at the cytoplasm of the tumor cells,while HIF-1α mainly at the nucleus.The expressions of CD34,VEGF and HIF-1α in the tail sign and tumor's margin were significantly higher than those in the MVD in the base center and tumor's center (P＜0.05).Positive correlations between expressions of VEGF and MVD,expressions of HIF-1α and MVD,as well as expressions of HIF-1α and VEGF were noted (r=0.960,P=0.040; r=0.964,P=0.036; r=0.998,P=0.002).Conclusion The angiogenesis in the periphery ofmeningiomas is much richer than that in the center; H1F-1α and VEGF may induce and promote the angiogenesis of meningiomas.
