Correlation between severity of leukoaraiosis and plasma levels of homocysteine and fibrinogen in patients with Binswanger disease
10.3760/cma.j.issn.1671-8925.2012.12.012
- VernacularTitle:高同型半胱氨酸、高纤维蛋白原等与Binswanger病脑白质疏松严重程度的相关性
- Author:
Ying-Shan YANG
1
;
Ai-Min WU
;
Zheng-Qi LU
;
Bing-Jun ZHANG
;
Xue-Jiao MEN
;
Xue-Qiang HU
Author Information
1. 广东省汕头市中心医院中山大学附属汕头医院神经内科
- Keywords:
Binswanger disease;
Leukoaraiosis;
Homocysteine;
Fibrinogen
- From:
Chinese Journal of Neuromedicine
2012;11(12):1238-1241
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between severity of leukoaraiosis (LA) and plasma levels of homocysteine and fibrinogen in patients with Binswanger disease (BD).Methods All patients with BD,admitted to our hospital from January 2005 to May 2011,were selected consistently with the diagnostic criteria of Bennett.The levels of plasma homocysteine (Hcy),fibrinogen (Hcy),low-density lipoprotein (LDL),apolipoprotein A (Apoa),apolipoprotein B (Apob),and high-density lipoprotein (HDL) were measured.According to the Kinkel's classification of BD,the severity of LA was graded as mild,moderate,or severe by its appearance under MRI.The relation between levels of plasma Hcy and Fib and severity of LA in BD patients were analyzed.Results Single factor analysis indicated that the dispositions of gender,age,hypertensive disease,stroke and hyperlipoidemia in BD patients with different severities of LA were significantly different (P＜0.05).The severity degree of LA was positively correlated with the levels of Hcy and Fib (P＜0.05).Ordered logistic regression analysis showed that female was severer than male in the severity of the LA in BD patients; age,stroke and level of plasma Fib were positively related to the severity of LA in BD patients (P＜0.05).Conclusion The high plasma level of Fib is an important factor for BD deterioration; reducing the level of plasma Fib may delay the aggravation of BD.
