Prevalence of non-motor symptoms in 440 patients with Parkinson ' s disease and their correlative factors
10.3760/cma.j.issn.1671-8925.2012.12.009
- VernacularTitle:440例帕金森病患者非运动症状的发生率及相关因素分析
- Author:
Jing-Hong MA
1
;
Hai-Qiang ZOU
;
Fei SUN
;
Jing AN
;
Biao CHEN
Author Information
1. 首都医科大学宣武医院神经内科
- Keywords:
Parkinson' s disease;
Non-motor symptom;
Depression
- From:
Chinese Journal of Neuromedicine
2012;11(12):1225-1228
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prevalence of non-motor symptoms in patients with Parkinson disease (PD) and their impact factors.Methods The detailed clinical information (onset age and disease duration) of 440 patients with idiopathic PD,admitted to our hospital from 2008 to 2011,were recorded.Several scales,including non-motor symptom screening scale,Hamilton depression rating scale (HAMD) and unified Parkinson's disease rating scale(UPDRS),were performed; these data were calculated with SPSS statistic software.Results Among the 440 PD patients,defecation incompletion (60.5％) and constipation (60％) enjoyed the highest frequency,followed by forgetfulness (56.6％),sweating (52％) and sadness (47.7％).Spearman rank correlation analysis showed that the sum of non-motor symptoms had a linear positive correlation with disease durations,HAMD total scores,and UPDRS Ⅱ and Ⅲ scores (P＜0.05).The frequency of daytime dribbling,taste/smelling abnormality,swallowing difficulty or choking,and constipation in patients with different disease durations were significantly different (P＜0.05); however,the frequency of forgetfulness,concentration and sadness in patients with different disease durations showed no significant differences (P＞0.05).Conclusion Gastrointestinal and psychiatric symptoms,and memory loss are the most common non-motor symptoms in PD patients; the sum of the non-motor symptoms increases with the increment of disease durations and the severity of PD and depression.
