Different times and procedures of postoperative radiation and chemotherapy affecting treatment efficacy of high-grade gliomas
10.3760/cma.j.issn.1671-8925.2012.11.013
- VernacularTitle:术后放、化疗时序对高级别脑胶质瘤疗效的影响
- Author:
Ju-Yi WEN
1
;
Fu-Qiang JIANG
;
Bin WANG
;
Jun ZHANG
;
Shan-Shan WU
;
Jing-Bo KANG
;
Qing NIE
Author Information
1. 海军总医院放射肿瘤科
- Keywords:
Glioma;
Malignancy;
Neo-adjuvant chemotherapy;
Concomitant chemo-radiotherapy;
Overall survival;
Progression free survival
- From:
Chinese Journal of Neuromedicine
2012;11(11):1143-1147
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effects of different times and procedures of postoperative radiation and chemotherapy on treatment efficacy of high-grade gliomas.Methods A prospective clinical trial was conducted in 71 patients with high-grade gliomas (HGG); they were separated randomly into two groups:one group including 39 patients received chemo-radiotherapy and adjuvant chemotherapy sequentially (RC+C) and the other group including 32 patients received neo-adjuvant chemotherapy and chemo-radiotherapy and adjuvant chemotherapy sequentially (C+RC+C).The clinical benefit rate (CBP),progression free survival (PFS) and overall survival (OS) were followed up after the treatment.Results No significant difference on CBP 5 months after treatment was noted between the two groups (P＞0.05),but the CBP in the C+RC+C group (87.5％) was significantly higher than that in the RC+C group (66.7％)8 months after treatment (P＜0.05).No significant difference on OS was noted between the two groups.The median PFS of patients in C+RC+C group was 11.5 months while that in the RC+C group was 8.6 months; the PFS of patients in C+RC+C group was significantly longer that in the RC+C group (P＜0.05).Conclusion Procedure of C+RC+C can prolong the PFS of patients with HGG.
