Association between rs1130864 of C-reactive protein single nucleotide polymorphisms and ischemic stroke
10.3760/cma.j.issn.1671-8925.2012.10.013
- VernacularTitle:C-反应蛋白rs1130864位点与缺血性卒中的相关性研究
- Author:
Fang CHEN
1
;
Qi ZHENG
;
Bao-Zhong DING
;
Xiao-Sheng ZHOU
;
Wen-Bin MA
;
Rui JIA
Author Information
1. 滨州医学院附属医院神经内科
- Keywords:
C-reactive protein;
rs1130864;
Ischemic stroke;
Gene
- From:
Chinese Journal of Neuromedicine
2012;11(10):1022-1025
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between the rs1130864 polymorphisms in C-reactive protein (CRP) gene and ischemic stroke (IS).Methods One hundred and twenty-eight patients with IS,admitted to our hospital from December 2010 to December 2011,another 112 healthy subjects without atherosclerotic vascular disease history were chosen in our study.Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was performed to detect the genotype ofrs1130864 site.Logistic multivariate regression analysis was employed to analyze the IS risk factors.Results The ratio of male patients,having history of hypertension,diabetes,hyperlipidemia,smoking and familial stroke in the patient group was significantly higher than that in control group (P＜0.05).The allele frequency,genotype and dominant model of rs1130864 site showed no statistically significant difference between the 2 groups (P＞0.05),but the recessive model ofrs1130864 site showed significant difference between the 2 groups (P＜0.05).Logistic regression analysis showed that male and having history of hypertension,diabetes and smoking in patients with rs1130864 recessive model (TT+CT) are the independent risk factors for IS (P＜0.05).Conclusion Male and history of hypertension,diabetes and smoking history in patients with rs1130864 recessive model (TT+CT) are independent risk factor for IS.
