Preliminary analysis of proton radiation therapy for chordomas in the skull base
10.3760/cma.j.issn.1671-8925.2012.09.008
- VernacularTitle:质子照射治疗颅底脊索瘤疗效初探
- Author:
Ji-Suo CHEN
1
;
Yu-Xia YANG
;
Xiang-Hua HU
;
Qing CHEN
;
Lei YU
Author Information
1. 万杰肿瘤医院
- Keywords:
Proton;
Photon;
Radiotherapy;
Chordoma
- From:
Chinese Journal of Neuromedicine
2012;11(9):895-898
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy of proton radiotherapy and photon radiotherapy for chordomas in the skull base. Methods A retrospective study was performed on the clinical data of 57 patients underwent stereotactic radiotherapy of their chordomas in the skull base; these patients were divided into proton radiotherapy group (n=31,treated with proton) and photon radiotherapy group (n=26,underwent photon radiation therapy).The efficacy was reviewed comparatively. Results Fifty-seven patients were followed up for 6-76 months in clinical symptoms and 6-72 months in imaging.The clinical symptom relief rate at 6 and 12 months after the treatment showed no significant difference between the 2 groups (x2=0.057,P=0.812; x2.144,P=0.143),while the progression-free survival and the overall survival showed significant difference between the 2 groups (x2=15.571,P=0.000; x20.232,P=-0.000).The proton radiotherapy group was superior to the photon radiotherapy group in total survival rate and relapse-free survival rate at 3 and 5 years after treatment (P＜0.05). Conclusion Proton radiotherapy is better than photon radiotherapy in the treatment of chordomas in the skull base; furthermore, proton radiotherapy has its obvious advantage for patients having relapsed chordomas after radiation therapy.
