Influence of course of disease on glycolipid metabolic parameters in drug-naive schizophrenia patients
10.3760/cma.j.issn.1671-8925.2012.08.023
- VernacularTitle:未用药的精神分裂症患者的病程对糖脂代谢指标的影响
- Author:
Xiao-Li WU
1
;
Zhao-Yu GAN
;
Zhi-Yong ZHONG
;
You-Nian LUO
;
Hong-Yin HAN
;
Jin-Bei ZHANG
Author Information
1. 中山大学附属第三医院
- Keywords:
Schizophrenia;
Glycolipid metabolism;
Course of disease
- From:
Chinese Journal of Neuromedicine
2012;11(8):847-850
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the course of disease and glycolipid metabolic parameters in drug-naive schizophrenia patients. Methods All 186 drug-naive schizophrenia patients,admired to our hospital from March 2010 to October 2011,were chosen in our study; relative glycolipid metabolic parameters at baseline were tested and Positive and Negative Syndrome Scale (PANSS) was performed on these patients; and the relationships between relative glycolipid metabolic indexes and both the course of disease and manipulated variable (age,gender,education level and severity of the disease) were assessed.Results Gender might play a significant role to some glycolipid metabolic parameters (waist-hip ratio [WHR]:β=0.364; high-density lipoprotein [HDL]:β=-0.248; triacyiglycerol [TG]:β=0.167 and lysophosphatidic acid (LPA):β=-0.198,P＜0.05); age might play an important role to some glycolipid metabolic parameters (body mass index [BMI]: β=0.213; WHR: β=0.286 and apolipoprotein B 100 [apoB100]:β=0.221,P＜0.05).Simultaneously,the severity of disease appeared to affect some glycolipid metabolic parameters (BMI:β-0.167; WHR:β=-0.150 and fasting blood-glucose [FBG]:β=0.172, P＜0.05). The course of disease hardly affected the majorities of relative glycolipid metabolic indices of drug-naive schizophrenia but LPa (β=0.173, P＜0.05). Conclusion The high metabolic abnormality incidence in schizophrenia patients maybe result from multi-factor interactions.
