Serum levels of vascular endothelial growth factor and C-reactive protein in patients with acute intra-cerebral hemorrhage
10.3760/cma.j.issn.1671-8925.2012.08.014
- VernacularTitle:血管内皮生长因子和C反应蛋白在急性脑出血患者血清的表达和临床意义
- Author:
Xi-Yi LIAO
1
;
Xin-Kun WANG
;
Ming-Xin ZHOU
Author Information
1. 广东省高州市中医院
- Keywords:
Acute intra-cerebral hemorrhage;
Vascular endothelial growth factor;
C-reactive protein
- From:
Chinese Journal of Neuromedicine
2012;11(8):812-814
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum levels of vascular endothelial growth factor (VEGF) and C-reactive protein (CRP) in patients with acute intra-cerebral hemorrhage and explore their significance. Methods Seventy-eight patients with acute intra-cerebral hemorrhage (the mild,n=39; the moderate,n=25; and the severe,n=14),treated in our hospital from August 2008 to August 2011,were selected in this research, and 78 healthy controls received healthy examination at the same time were also selected.Enzyme-linked immunoassay (ELISA) was used to detect the serum level of VEGF,while immunoturbidimetry was used to detect the serum level of CRP. Results The levels of VEGF and CRP of acute intra-cerebral hemorrhage patients were all significantly higher than those of healthy persons (P＜0.05); VEGF and CRP serum levels in severe, were decreased in turn with significant difference (P＜0.05).And VEGF and CRP serum levels of dead patients (n=16) were also significantly higher than those of survive patients (n=62, P＜0.05). Conclusion VEGF and CRP serum levels of acute intra-cerebral hemorrhage patients are significantly higher than those of healthy persons, and they all have strong positive relationship with the seventy and prognosis of the disease.
