Bioinformatic analysis of genes related to Alzheimer's disease

VernacularTitle:阿尔茨海默病相关基因的生物信息学分析
Author: Chang-Zheng LI ¹ ; Hui WANG ; Wei-Ran L(U) ; Ye ZHOU
Author Information

1. 南方医科大学附属南方医院
Keywords: Alzheimer's disease; DNA microarray; Bioinformatics
From: Chinese Journal of Neuromedicine 2012;11(8):767-769
CountryChina
Language:Chinese
Abstract: Objective To investigate the genes associated with Alzheimer's disease (AD) by bioinformatics methods to provide new thoughts for basic research and clinical treatment of AD.Methods The microarray data of AD-related genes were downloaded from the Gene Expression Omnibus (GEO) database and analyzed by bioinformatics methods using String,KEGG and Panther databases.Results Of all the 34 differentially expressed genes,25 were found to encode proteins with interactions; they referred to multiple biological pathways,biological processes and molecular functions.Conclusion The pathogenesis of AD involves multiple genes,especially genes with Ca2+ signaling,and investigations of these genes may provide valuablc insights into the mechanism of AD.