Short- and long-term effects of thrombolysis in patients with acute cerebral infarction and its influencing factors
10.3760/cma.j.issn.1671-8925.2012.07.018
- VernacularTitle:急性脑梗死溶栓治疗近、远期疗效及影响因素分析
- Author:
Zhi-Zhong LIANG
1
;
Yu-Huan LI
;
Fei LI
;
Qing-Ge LIU
;
Zhi-Xing PAN
Author Information
1. 南方医科大学附属南海医院
- Keywords:
Cerebral infarction;
Thrombolysis;
Urokinase;
Short-tarm efficacy;
Long-term efficacy;
Influencing factor
- From:
Chinese Journal of Neuromedicine
2012;(7):717-721
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To analyze the short-term (24 h) and long-term (3 months) effects of thrombolysis in patients with acute cerebral infarction and its influencing factors.[Methods]Fifty-three patients with acute ischemic stroke,admitted to our hospital fiom January 2006 to December 201 i,were treated with urokinase (UK);the effects were observed by NIHSS and Modified Rankin Scale (mRS).Influencing factors were analyzed by Stepwise logistic regression.[Results] Twenty-eight patients had good outcome (52.8％) 24 h after thrombolytic therapy;multivariate logistic regression indicated that gender,interval between onset and receiving thrombolytic therapy,and fibrinogen level before thrombolytic therapy were the independent predictors of good outcome (P=0.007,0.017 and 0.001,respectively).Forty patients (75.4％) had good outcome 3 months after thrombolytic therapy;multivariate logistic regression indicated that the scores of NIHSS before thrombolysis and 24-h thrombolytic effect were the independent predictors of good outcome (both P=0.002).[Conclusion] Risk factors associated with short- and long-term thrombolytic effects might be different,which needs us make a difference in clinical work.
