Vitamin B levels in blood serum and brain MRI changes in patients with H-type hypertension
10.3760/cma.j.issn.1671-8925.2012.06.018
- VernacularTitle:H型高血压患者血清B族维生素水平以及脑影像学变化的研究
- Author:
Jing-Feng FAN
1
;
Ping LIU
;
Xiu-Li CAO
Author Information
1. 辽宁省大连市友谊医院
- Keywords:
H-type hypertension;
Folic acid;
Vitamin B12;
White matter lesion
- From:
Chinese Journal of Neuromedicine
2012;11(6):619-621
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the levels of plasma homocysteine (Hcy),serum folic acid and serum vitamin B12 in patients with H-type hypertension to provide some reference for intervening the white matter lesions. Methods One hundred and ten patients with hypertension (78 with H-type hypertension and 32 with hypertension),admitted to our hospital from April 2010 to March 2011,and other 50 healthy controls were chosen in our study; plasma Hcy level and serum folic acid and vitamin B12 levels were measured by using radioimmunoassay among control group,hypertension group and H-type hypertension group.White matter lesion changes of all patients were evaluated by MRI. Results The plasma Hcy level and serum folic acid and vitamin B12 levels in H-type hypertension group were significantly higher than those in control group and hypertension group (P＜0.05); the degree of white matter lesions was significantly different between each 2 groups (P＜0.05): the patients of H-type hypertension group had the most obvious white matter lesions, following by hypertension group and control group. Conclusion The patients with H-type hypertension have decreased folic acid and vitamin B12 levels and severe white matter lesion changes, which might be correlated with hyperhomocysteinemia.
