Early magnesium sulfate combined with Nimodipine injection in treating patients with diffuse axonal injury
10.3760/cma.j.issn.1671-8925.2012.05.013
- VernacularTitle:硫酸镁联合尼莫地平治疗弥漫性轴索损伤的临床分析
- Author:
Zhun ZHANG
1
;
Yi-Quan KE
;
Qing-Hua WANG
;
Zhi-Ping CHEN
Author Information
1. 南方医科大学珠江医院
- Keywords:
Magnesium sulfate;
Diffuse axonal injury;
Magnesium
- From:
Chinese Journal of Neuromedicine
2012;11(5):489-492
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the serum level of magnesium in patients with diffuse axonal injury (DAI) and the effect of early magnesium sulfate combined with Nimodipine injection on the prognoses of these patients with DAI. Methods Ninety-nine patients with DAI, admitted to our hospital from September 2006 to June 2010,were randomly divided into 2 groups.The serum level of magnesium was detected on admission. And both groups were treated with Nimodipine injection intravenously 0.5-1.0 mg/h for 7 consecutive d after admission.The experimental group was treated with 250 g/L MgSO4 injection for 3 consecutive d and the control group was treated without MgSO4.Follow-up was performed to observe the relationship between prognoses and both serum level of magnesium on admission and early MgSO4 treatment. Results No significant difference on fatality rate was noted between the experimental group and the control group; however,the experimental group enjoyed a significantly higher good recovery rate and moderate disability rate than the control group (P＜0.05); No significant correlation between the serum level of magnesium and Glasgow outcome scale was noted in both groups. Conclusion The serum level ofmagnesium on admission can't affect the prognoses.As compared with use of nimodipine alone,combined early treatment of 250 g/L magnesium sulfate with continuous intravenous infusion couldn't decrease the mortality rate,but can decrease the severe disability rate and improve the prognoses of patients and enhance their life qualities.
