Effect of high frequency stimulation of subthalamic nucleus on discharge changes of globus pallidus nucleus in primate models of Parkinson's disease
10.3760/cma.j.issn.1671-8925.2012.05.006
- VernacularTitle:高频电刺激丘脑底核对偏侧帕金森病猴模型苍白球内侧部神经元放电的影响
- Author:
Jing-Jun LI
1
;
Kai ZHANG
;
Yu MA
;
Jian-Guo ZHANG
;
Ying ZHANG
;
Wen-Han HU
;
Fan-Gang MENG
Author Information
1. 北京市神经外科研究所
- Keywords:
Parkinson's disease;
High frequency stimulation;
Subthalamic nucleus;
Electrophysiological recording;
Rhesus monkey
- From:
Chinese Journal of Neuromedicine
2012;11(5):459-463
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanism of high frequency stimulation (HFS) of subthalamic nucleus (STN) in treating primate models of Parkinson's disease (PD). Methods Two rhesus monkeys were injected 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into unilateral brain to induce the PD models; rhesus monkey models were implanted with glass recording electrodes and stimulating electrodes into the globus pallidus intemus (GPi) and STN, respectively. Extracellular recording was used to investigate the spikes and analyze the firing activity of GPi before and during STN-HFS. Results The spontaneous firing of GPi neurons on the normal side of PD monkeys was more regular than that on the abnormal side,and the frequency of firing was (44.38±13.66)spike/s and (50.57±15.53)spike/s respectively, without significant difference (P＞0.05). During STN-HFS, 4 neuronal activity changes existed, including incomplete inhibition, complete inhibition, increase of excitability and no change.STN-HFS could cause inhibition in most of the GPi neurons on both sides and the average inhibition rate on the abnormal side was 56.29％±29.66％,which was higher than that on the normal side(36.03％±35.25％),with statistically significant difference(P＜0.05).Conclusion HFS would do a certain extent suppression to the abnormal activity of STN neurons,resulting in a re-equilibrium in the neuronal activity of the basal ganglia motor circuit and the improvement of PD symptoms.
