Clinical efficacy of Yindanxinnaotong soft capsules combined with zopiclone in treatment of elderly patients with chronic insomnia
10.3760/cma.j.issn.1671-8925.2012.04.018
- VernacularTitle:银丹心脑通软胶囊联合佐匹克隆治疗老年慢性失眠的临床疗效
- Author:
Lian WANG
1
;
Ling WEI
;
Qian LIU
Author Information
1. 成都军区昆明总医院
- Keywords:
Yindanxinnaotong soft capsule;
Zopiclone;
Insomnia;
Combined medication;
The elderly
- From:
Chinese Journal of Neuromedicine
2012;11(4):405-409
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic effect of Yindanxinnaotong soft capsules combined with zopiclone on elderly patients with chronic insomnia. Methods Ninety-two elderly patients with chronic insomnia, admitted to our hospital from January 2010 to August 2011, were randomly assigned into Yindanxinnaotong soft capsule treatment group (n=30),zopiclone treatment group (n=31) and combined treatment group (n=31); these patients received treatment for 4 weeks. With pre-treatment and post-treatment self-control statistical method,Pittsburgh sleep quality index (PSQI) was used to evaluate the sleep quality, and polysomnogram was used to detect the changes in sleep architecture. Results All of 3 treatment groups enjoyed considerably improved PSQI, scores especially after 4 weeks of treatment; the improvement in the combined treatment group was significantly more obvious than that in the Yindanxinnaotong soft capsule treatment group and zopiclone treatment group (P＜0.05); the number of patients enjoyed S3 and S4 during relatively non-rapid eye movement sleep (REM sleep) was obviously increased 2 weeks after treatment; the number was further increased 4 weeks after treatment with combined treatment group enjoying the best results; most of the patients could recover the sleep continuity.All of 3 treatments considerably prolonged total sleep time,slow wave sleep (S3+S4) time and relatively rapid eye movement sleep (REM sleep) time,which markedly repaired the disruption in sleep architecture and improved sleep quality. The sleep quality of the elderly from combined treatment group could be more effectively and rapidly improved as compared with that of the other 2 groups; Yindanxinnaotong soft capsules used alone could receive the same result,but it need a longer time. Conclusion The combination of Yindanxinnaotong soft capsules and zopiclone could be an alternative method in the treatment of patients with chronic insomnia.
