Correlation of fibrinogen, D-dimer and carotid atherosclerosis plaque in acute cerebral infarction
10.3760/cma.j.issn.1671-8925.2012.03.012
- VernacularTitle:急性脑梗死患者血清纤维蛋白原、D-二聚体与颈动脉粥样硬化斑块的相关性研究
- Author:
Wen XIAO
1
;
Cang-Xia LI
;
Hai-Long XUE
;
Xiu-Li JIA
Author Information
1. 解放军第三医院
- Keywords:
Cerebral infarction;
Carotid atherosclerotic plaques;
Fibrinogen;
D-dimer
- From:
Chinese Journal of Neuromedicine
2012;11(3):266-268
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between fibrinogen,D-dimer and carotid atberosclerosis plaque in patients suffering acute cerebral infarction. Methods The present study enrolled 120 patients with acute cerebral infarction who had sought medical treatment in our department from April 2009 to April 2011 (group A),60 contemporary patients with carotid atherosclerosis plaque (group B) and 80 healthy adults who had undergone health check-ups at the same period (group C).The level of serum D-dimer was detected by double antibody sandwich method,the fibrinogen content was detected by an automatic hemagglutination analyzer (STA-COMPACT,STAGO),carotid atherosclerotic plaques and the carotid interior and medial thickness (IMT) were measured by carotid artery color Doppler ultrasound. Comparisons were made between the 3 groups. Results The serumal level of fibrinogen,D-dimer content and carotid IMT in the 3 groups decreased significantly from group A to B toC (P＜0.05).The serumal levels of fibrinogen and D-dimer in the patients with progressive stroke were significantly higher than in the patients with non-progressing stroke (P＜0.05).In patients with acute cerebral infarction, the severity of carotid atherosclerotic plaque was positively correlated with the serumal levels of fibrinogen and D-dimer (r=0.426, P=0.006; r=0.535,P=0.001). Conclusions Fibrinogen and D-dimer may have a role in the occurrence and development of acute cerebral infarction and may be closely associated with the progression of the condition.Since D-dimer and fibrinogen are reactants at the acute phase, inflammation may be more related to atherosclerosis than is hypercoagulation.
