Effect of simvastatin on chronic temporal epilepsy in rats
10.3760/cma.j.issn.1671-8925.2012.03.008
- VernacularTitle:辛伐他汀抑制慢性颞叶癫痫形成的初步研究
- Author:
Zhi-Hui HUO
1
;
Zhi-Guo LIN
;
Hong SHEN
Author Information
1. 哈尔滨医科大学附属第一医院
- Keywords:
Simvastatin;
Epilepsy;
Neuron;
Mossy fibersprouting;
Gliocyte
- From:
Chinese Journal of Neuromedicine
2012;11(3):250-253
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the effect of administration of simvastatin on pathological changes of brain tissues from rats with chronic temporal lobe epilepsy (TLE) and epileptic seizure of these rats. Methods Seventy-two adult male healthy Wistar rats were randomly divided into control group,saline treatment group and Simvastatin (Sim) treatment group (n=24).Rats of the control group were only received oral administration of saline into unilateral ventricle; status epilepticus (SE) in rats of saline treatment group and Sim treatment group were induced by kanic acid (KA) injection into unilateral ventricle; 0.5 h after SE,rats of the saline treatment group were treated with oral administration of saline once daily for 14 consecutive days; rats of the Sim treatment group were subjected to oral administration of simvastatin once daily for 14 consecutive days.Rats were sacrificed 3 d, 4,5 and 6 months after simvastatin or saline administration.Timm's staining,Nissl staining,and GFAP staining were employed to observe the pathological changes of these rat brain tissues; and the seizures were observed and scored according to Racine's grading. Results Pathological changes showed that loss of neurons in the CA3and the dentate gyrus was obviously restrained,speed of mossy fiber sprouting was significantly slowed down,and the grade of SE was significantly decreased in rats of the Sim treatment group as compared with those in rats of saline treatment group (P＜0.05). Conclusion Simvastatin may have long-term neuroprotective effect on process of chronic TLE.
