Reconstruction of frontal sinus and repair of cerebrospinal fluid leakage with complex of shapememory alloy brace and artificial dura in dog models
10.3760/cma.j.issn.1671-8925.2012.03.007
- VernacularTitle:镍钛合金支架-脑膜建复合体重建额窦修补脑脊液鼻漏的实验研究
- Author:
Zhi-Qiang WANG
1
;
Song-Tao QI
Author Information
1. 赤峰学院附属医院
- Keywords:
Complex of Nitinol brace and NormalGEN;
Skull base reconstruction;
Cerebrospinal fluid leakage;
Frontal sinus reconstruction
- From:
Chinese Journal of Neuromedicine
2012;11(3):246-249
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the therapeutic effect of a new material--complex of shape-memory alloy brace and artificial dura (nitinol brace and NormalGEN) on reconstruction of frontal sinus and repair of cerebrospinal fluid leakage on dog models of lateral media skull base defect.Methods Seven adult healthy dogs were induced into models of frontal sinus defect and cerebrospinal fluid leakage; complex of nitinol brace and NormalGEN assisted by its corresponding apparatus was employed to reconstruct the defect and repair the leakage.The cranial profile,wound healing and leakage after operation were observed. Three months after the operation, cranial projections of X-ray,three-dimensional reconstruction of CT and 1.5T MRI were detected,and the histopathalogical outcome was noted. Results Seven dog models of frontal sinus defect and cerebrospinal fluid leakage were successfully established; 6 received reconstruction of frontal sinus and repair of cerebrospinal fluid leakage and survived without any complications as continuous leakage of cerebrospinal fluid,local tissue eminence and neurological function defect; 1 dead 5 d after the operation.The imaging detection showed that the nitinol brace was clear with satisfactory position without shift and artifact. Histopathalogical outcome showed that granulation tissue,which substituted NormalGEN,grew around the brace with a great quantity of fibroblast. Conclusion The complex of nitinol brace and NormalGEN assisted by its corresponding apparatus is suitable for reconstructing frontal sinus and repairing cerebrospinal fluid leakage in dog models.
