Genetic polymorphism of methionine synthase reductase in young and middle-aged patients with cerebral infarction
10.3760/cma.j.issn.1671-8925.2012.01.009
- VernacularTitle:中青年脑梗死患者蛋氨酸合成酶还原酶基因多态性研究
- Author:
Ai-Ling ZHANG
1
;
Lai-Hui FENG
;
Jun-Fang TENG
;
Xin-Yu ZHAO
Author Information
1. 郑州人民医院
- Keywords:
Cerebral infarction;
Methionine synthase reductase;
Gene polymorphism;
Homocysteine
- From:
Chinese Journal of Neuromedicine
2012;11(1):37-41
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between methionine synthase reductase (MTRR) gene polymorphism and cerebral infarction in young and middle-aged patients. Methods The genotype of MTRR A66G was analyzed by polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) and the plasma homocysteine (Hcy) level was measured by high performance liquid chromatography in 105 young and middle-aged patients with cerebral infarction and 116 age-matched healthy controls. Results The genotype distribution and allele frequencies of MTRR A 66G gene between the 2 groups had no statistical significance (P＞0.05).Stratified analysis,performed according to whether cerebral infarction was complicated with hypertension,diabetes or coronary heart disease,indicated that the frequencies ofGG genotype and G allele in cerebral infarction patients without complications were obviously higher than those in controls (36.4％ vs.23.3％,62.1％ vs.52.2％),but no statistical significance was noted between them (P＞0.05).No statistical difference was observed between cerebral infarction patients with complications and controls (P＞0.05). The mean plasma Hcy level in patients and controls with GG genotype was significantly higher than that in patients and controls with AA genotype (P＜0.05). Conclusion No association between MTRR A 66G polymorphism and cerebral infarction is noted in young and middle-aged patients, while GG mutant homozygous ofMTRR A66G gene can significantly raise the plasma Hcy level.
