Quantitative relation between scores of subarachnoid hemorrhage and scores of neurological scale in mouse models of subarachnoid hemorrhage

VernacularTitle:小鼠蛛网膜下腔出血模型中出血量评分与神经功能评分的量化关系分析
Author: Fan-Fan CHEN ¹ ; Wei QUAN ; Jian-Ping LU
Author Information

1. 广东省广州市第一人民医院
Keywords: Subarachnoid hemorrhage; Neurological scale; Quantitative analysis
From: Chinese Journal of Neuromedicine 2012;11(1):27-30
CountryChina
Language:Chinese
Abstract: Objective To observe the quantitative relation between new subarachnoid hemorrhage (SAH) grading and scores of Garcia neurological scale in mouse models of SAH.Methods Mouse models of SAH were induced by filament perforation; neurological scale was performed 24 h after SAH; and then,these mouse models were sacrificed and performed SAH grading;the relation between scores of neurological scale and SAH grading was analyzed by SPSS 13.0 software.Results Fourteen of 21 mice survived after SAH. The higher the SAH grading, the worsen the neurological scale results; these 2 were negatively correlated (r=-0.841,P=0.000). Conclusion The scores of Garcia neurological scale and SAH grading has a quantitative negative relation and can be used to evaluate the hemorrhage in mouse models induced by filament perforation.