Expression of spleen tyrosine kinase in glioma of different grades and its relation with CyclinD1 level
10.3760/cma.j.issn.1671-8925.2011.12.018
- VernacularTitle:脾酪氨酸激酶在不同等级胶质瘤中的表达及其与周期素1水平的相关性
- Author:
Xu LIU
1
;
Man-Hui LI
;
Yang-Qiang ZOU
;
Tao ZHENG
;
Tao KUANG
Author Information
1. 贵州航天医院
- Keywords:
Spleen tyrosine kinase;
Cyclin D1;
Glioma
- From:
Chinese Journal of Neuromedicine
2011;10(12):1267-1269
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the human brain spleen tyrosine kinase(Syk)expression and its correlation with CyclinD1 level.Methods Forty-six glioma samples,confirmed by pathology and performed surgical resection in our hospital from January 2005 to January 2010,including 13 of grade I,9 of grade Ⅱ,5 of grade Ⅲ and 19 with glioblastoma multiforme of grade IV,were chosen; another 5 normal brain tissues from patients with cerebral trauma were chosen as controls.RT-PCR was employed to detect the mRNA levels of Syk and CyclinD 1; and their correlation was analyzed.Results As compared with the normal brain tissues,gliona tissues of grade Ⅰ,l,Ⅲ and IV enjoyed significantly lower mRNA level of Syk and obviously higher mRNA level of CyclinD 1(P＜0.05).The mRNA level of Syk was significantly decreased with the increase of pathological grades,while the mRNA level of CyclinD1 was in the opposite position (P＜O.05); Expression level of Syk in gliomas was negatively significantly correlated with that of CyclinD1(r=-0.832,P--0.000).Conclusion Decreased or missed Syk expression in glioma might suggest that it may have a tumor suppressor gene function,which might be related to decreased expression of CyclinD 1 in glioma.
