Effect of berberine on spatial memory in transgenic mice with Alzheimer′s disease
10.3760/cma.j.issn.1671-8925.2011.12.011
- VernacularTitle:小檗碱对阿尔茨海默病转基因鼠空间记忆力的影响
- Author:
Fei-Qi ZHU
1
;
Guang-Jian LIU
;
Ying MA
;
Zhong PEI
Author Information
1. 汕头大学医学院附属粤北人民医院
- Keywords:
Alzheimer′s disease;
Berberine;
Spatial memory;
Aβ40/42
- From:
Chinese Journal of Neuromedicine
2011;10(12):1234-1237
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect ofberberine on the spatial memory oftransgenic mice with Alzheimer′s disease (caused by Swedish double mutation (KM670/671NL) of amyloid precursor protein [Swe-APP]).Methods Twenty-four 6-month-old APP/SWE mice were randomly divided into 4 groups:model group,low-dose berberine treatment group,medium-dose berberine treatment group and high-dose berberine treatment group(n=6).Except mice of the model group,the mice in the other 3 groups were given berberine at dosage of 10(mg/kg·d),50(mg/kg-d) and 200 (mg/kg.d),respectively,by intragastric administration once daily to 10 months′ old.The spatial memory was detected by Morris water maze test,and the levels of amyloid β(Aβ40 and Aβ42)in the brain tissues were measured by enzyme linked immunosorbent assay(ELISA).Results As compared those in mice of the model group,the escape latency decreased significantly,the frequency of crossing the platform obviously increased and the levels of Aβ40 and Aβ42 decreased significantly in mice of each berberine treatment group on the 6th d of detection(P＜0.05) Conclusion Berberine might improve the spatial memory of APP/SWE mice by decreasing the levels of Aβ 40/42.
