Metabolic abnormality of patients with first-episode schizophrenia and effect of olanzapine on them
10.3760/cma.j.issn.1671-8925.2011.11.021
- VernacularTitle:首发精神分裂症患者代谢异常分析及奥氮平对其影响
- Author:
Xiao-Li WU
1
;
Lei-Jun LI
;
Wen-Tao WU
;
Zhuang KANG
;
Jin-Bei ZHANG
Author Information
1. 中山大学附属第三医院
- Keywords:
Schizophrenia;
Metabolic abnormality;
Olanzapine
- From:
Chinese Journal of Neuromedicine
2011;10(11):1160-1163
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the metabolic abnormality in patients with first-episode schizophrenia and effect of atpical antipsychotics olanzapine on them.Methods Thirty patients with first-episode schizophrenia,admitted to our hospital from February 2010 to February 2011,and 40healthy controls were chosen in our study; patient group was given oral olanzapine for 4 week.The height,weight,waistline and hipline were measured before and after treatment,and the total cholesterol (TC),triglyceride(TG),high-density lipoprotein(HDL),low-density lipoprotein(LDL),apolipoprotein AI(aPOAI),apolipoprotein B100(aPOB100),lipoprotein a(LPa),fasting blood-glucose,fasting insulin and C peptide levels were detected before and after treatment; and the insulin resistance(IR)index,waist hip ratio(WHR)and body mass index(BMI)were calculated before and after treatment; metabolic index were compared between patients and controls,and patients before and after the treatment.Results The HDL and aPOA1 levels in patient group were significantly lower,and the WHR,IR index,fasting insulin and C peptide levels were obviously higher as compared with those in the controls(P＜0.05).The BMI,waist circumference,WHR,the IR index,the insulin,TC,TG,LDL and aPOB100 levels after treatment were significantly increased as compared with those before treatment(P＜0.05).Conclusion There may be some inborn metabolic abnormality factors in patients with first-episode schizophrenia; the high incidence of metabolic abnormality in patients with schizophrenia may be the result of combined action from antipsychotics and inherit susceptibility.
