Association between polymorphism of 5-hydroxy tryptamine 2A receptor T102C gene and poststroke depression

VernacularTitle:5-羟色胺2A受体T102C基因多态性与卒中后抑郁的关联研究
Author: Cui CHEN ¹ ; Zhen-Hua LIU ; Ai-Min CHEN ; Lian-Xu ZHAO
Author Information

1. 南方医科大学珠江医院
Keywords: Depression; Stroke; 5-hydroxy tryptamine; Gene polymorphism
From: Chinese Journal of Neuromedicine 2011;10(11):1119-1121
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship between polymorphism of 5-hydroxy tryptamine 2A(5-HT2A)receptor T102C gene and post-stroke depression(PSD),and investigate the heredity-related pathogenesis of PSD.Methods The polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP)method was applied to test the allele frequencies and genotype of 5-HT2A receptor T102C gene in 97 patients with PSD and 72 patients without depression after stroke.Results The frequency of mutant C allele in patients with PSD was significantly lower than that in patients without depression(P＜0.05),and the frequency of homozygote C/C genotype in patients with PSD was also obviously lower than that in patients without depression(P＜0.05).Conclusion The 5-HT2A receptor T102C gene may be the susceptibility gene of PSD and C allele may be the protective factor of subjects suffering from PSD.