Expression of afamin in serum of patients with unruptured intracrauial aneurysm and its significance
10.3760/cma.j.issn.1671-8925.2011.11.009
- VernacularTitle:afamin在未破裂颅内动脉瘤患者血清中的表达及意义
- Author:
Yong-Hua ZHU
1
;
You-Ye YANG
;
Shao-Hua LIN
;
Song-Tao QI
;
Han-tian NG HUA
;
Wei LIAO
;
Zi-Hui HU
;
Liang-Ming LI
;
Qi-Chang LIN
;
Yong LUO
Author Information
1. 中山大学附属中山医院(中山市人民医院)
- Keywords:
Intracranial aneurysm;
Afamin;
Serum protein;
Two-dimensional differential in-gel electrophoresis
- From:
Chinese Journal of Neuromedicine
2011;10(11):1115-1118
- CountryChina
- Language:Chinese
-
Abstract:
Objective To search the differenially expressed proteins in the serum of patients with unruptured intracranial aneurysm.Methods Eight patients with unruptured intracranial aneurysm,admitted to our hospital from July 2007 to September 2009,and 8 healthy adults(controls)were recruited in our study; two-dimensional differential in-gel electrophoresis(2D DIGE)and matrix-assisted laser desorption/ionization-time of flight mass spectrometry(MALDI-TOF-MS)were employed to analyze and identify the differentially expressed proteins in the serum of these patients and controls.Results As compared with the control group,patients with unruptured intracranial aneurysm had 29 differentially expressed proteins those enjoyed more than 1.5 folds differences; protein at spot 579was expressed as low as 1.81 folds in the serum of patients with unruptured intracranial aneurysm as compared with that in controls(P=0.008); the protein was identified as afamin using MALDI-TOF-MS.Conclusion The low expression of afamin in patients with unruptured intracranial aneurysm probably contributes to the formation and expansion of intracranial aneurysm.
