Chlorpromazine enhances high-voltage electroencephalogram spindles and facial twitching in freely moving rats

VernacularTitle:氯丙嗪对大鼠皮层HVSs节律及面部抽搐增强作用研究
Author: Chen YANG ¹ ; Lei CHEN ; Xiao-Zhan CHANG ; Sun-Nan GE ; Jun-Ling ZHU ; Guo-Dong GAO
Author Information

1. 第四军医大学唐都医院
Keywords: Chlorpromazine; High-voltage spindle; EEG; Electromyography
From: Chinese Journal of Neuromedicine 2011;10(11):1106-1109
CountryChina
Language:Chinese
Abstract: Objective To explore the effect of chlorpromazine on neocortical high-voltage spindles(HVSs)and facial twitching in freely moving normal adult rats.Methods Continuous video,neocortical electroencephalogram(EEG)and facial electromyography(EMG)were recorded simultaneously for at least 6 h in freely moving rats.The number and mean duration of HVSs,and the facial muscular activity were analyzed after administration of chlorpromazine.Results HVSs spontaneously appeared in behavioral waking-immobility rats with accidental hyperspasmia.After rats being administrated with chlorpromazine at a dose of 1.5(mg/kg)and 3.0(mg/kg),the facial rhythmic muscular activity increased,the duration of rhythmic muscular activity prolonged,the number of HVSs increased and the mean duration of HVSs prolonged.Conclusion Chlorpromazine could enhance the physiological HVSs and facial twitching,indicating that the side effect at the extrapyramidal system of antipsychotic maybe relate to HVSs and dopamine receptor may contribute to the regulation of HVSs.