Quantitative 3D simulation research of MRI diffusion tensor white matter fiber tractography in patients with multiple sclerosis
10.3760/cma.j.issn.1671-8925.2011.10.020
- VernacularTitle:多发性硬化患者MRI扩散张量成像脑白质束示踪的三维仿真定量研究
- Author:
Yang YANG
1
;
Zhuang NG KA
;
Yan ZOU
;
Si-Chi KUANG
;
Hong SHAN
;
Bing HU
Author Information
1. 中山大学附属第三医院
- Keywords:
White matter fiber tractography;
Multiple sclerosis;
MRI;
Diffusion tensor imaging
- From:
Chinese Journal of Neuromedicine
2011;10(10):1048-1052
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the quantitative fiber tractography variations and 3D simulation patterns in patients with multiple sclerosis (MS),and assess the correlation between quantitative fiber tractography and scores of expanded disability status scale (EDSS).Methods MR diffusion tensor imaging was applied in 28 MS patients and 28 age-matched healthy volunteers.Then,quantitative tractography was generated in all subjects; and mean numbers of tracked lines and fiber density were measured.Paired-samples t tests were used to compare tracked lines and fiber density in MS patients with those in controls.Analysis of variance of ADC value and FA value was applied to MS patients having demyelinating plaque and normal appearing white matter,and controls.Linear regression model was used to determine the relationship between quantitative fiber tractography and scores of EDSS in MS patients.Results Tractography's tracked lines (2220±100) and fiber density (0.75±0.04) in MS patients were less than those in controls (2750±70) and (0.93±0.02,P＜0.05).In MS patients having plaque and normal appearing white matter,and controls,the ADC values of ROI were (1.23±0.13)× 10-3 mm2/s,(0.76±0.09)×10-3 mm2/s and (0.63±0.10)×10-3 mm2/s,respectively,with a gradual declined trend; and the FA values were 0.24±0.04,0.42±0.07 and 0.48±0.06,respectively,with a gradual increased trend; significant differences were noted between each 2 groups (P＜0.05).Both tracked lines and fiber density were found negative correlations with scores of EDSS in MS patients (P＜0.05).Conclusion Damages of white matter tracts in MS patients can be detected by diffusion tensor fiber tractography,and it provide more space information than conventional MRI.
