Interventional thrombolysis with Urokinase and Tirofiban in patients with cerebral venous sinus thrombosis
10.3760/cma.j.issn.1671-8925.2011.10.015
- VernacularTitle:尿激酶联合替罗非斑在颅内静脉窦血栓形成介入性治疗中的应用
- Author:
Lei FENG
1
;
Guang FENG
;
Dao-Hua HE
;
Li PAN
;
Lian-Ting MA
Author Information
1. 南方医科大学
- Keywords:
Venous sinus thrombosis;
Endovascular treatment;
Thrombolytic therapy
- From:
Chinese Journal of Neuromedicine
2011;10(10):1031-1033
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and risk of endovascular thrombolysis with Urokinase and Tirofiban in patients with cerebral venous sinus thrombosis (CVST).Methods Nine patients with severe CVST were performed selective intravenous sinus Urokinase and Tirofiban thrombolysis combined with mechanical thrombus maceration in our hospital from January 2009 to January 2011; their clinical data and treatment efficacy were analyzed.Results Normal cerebrospinal fluid (CSF) pressure was noted in 8 patients before discharging from the hospital; DSA indicated that 7 achieved complete recanalization of main branch of the venous sinus,cortical veins and deep vein.Only 1 achieved reeanalization of sinuses partly,and partial compensation was noted in the cortical veins.No operation-related complication was noted during and after the surgery.After thrombolysis,symptoms and signs of 8 patients improved obviously,and headache disappeared in 7 of them with only mild degree in 1; 1 patient died.Conclusion Intravenous sinus Urokinase and Tirofiban thrombolysis is an effective and safe method for patients with potentially catastrophic intracranial dural sinus thrombosis.
