Changes of serum albumin and globulin levels and albumin-globulin ratio in patients with cerebral infarction
10.3760/cma.j.issn.1671-8925.2011.10.013
- VernacularTitle:脑梗死患者血清白蛋白、球蛋白水平及其比值变化研究
- Author:
Wen-Wen WANG
1
;
Lü-Qian HUANG
Author Information
1. 贵州省兴义市人民医院
- Keywords:
Cerebral infarction;
Albumin;
Globulin;
Prognosis
- From:
Chinese Journal of Neuromedicine
2011;10(10):1023-1026
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of serum albumin and globulin levels andalbumin-globulin ratio in patients with cerebral infarction,and their prognostic value.Methods Onehundred and twenty patients with acute ischemic stroke,admitted to our hospital from June 2006 to June2010,were chosen as Group Ⅰ; Group Ⅱ included 110 subjects matched with Group Ⅰ for age,medications,and clinical risk factors of stroke; and Group Ⅲ was composed of 90 healthy volunteers,matched for agewith Group Ⅰ and Ⅱ.Serum albumin and globulin levels,albumin-globulin ratio,fibrinogen level andnumber of peripheral blood cells in the 3 groups were compared; and the prognosis of subjects with analbumin-globulin ratio above 1.45 or less were compared between each 2 groups after 2-year-follow-up.Results Serum globulin,fibrinogen and leucocyte levels in Group Ⅰ were significantly higher than thosein Group Ⅱ and Ⅲ,and those in Group Ⅱ were obviously higher than those in Group Ⅲ (P＜0.05).Serumalbumin level and albumin-globulin ratio in Group Ⅰ were significantly lower than those in Group ⅡⅡ andⅢ,and those in Group Ⅱ were obviously lower than those in Group Ⅲ (P＜0.05).To the end of follow-up,the incidence of recurrent cerebrovascular disease were 24.1％,18.5％ and 2.3％ in Group Ⅰ,Ⅱ and Ⅲ,respectively(P＜0.05).Subjects with albumin-globulin ratio less than 1.45 in Group Ⅰ and Ⅱ had 3.6 timesof risk for a subsequent vascular event as compared with their counterparts with albumin-globulin ratioabove 1.45.Conclusion Serum albumin and globulin levels and albumin-globulin ratio have a closecorrelation with cerebral infarction.The patients with low albumin-globulin ratio have increased risk ofcerebrovascular disease as compared with subjects of normal albumin-globulin ratio in subjects with cerebral infarction and high-risk cerebrovascular disease.
