Primary Sjogren syndrome combined with central nervous system damage: a clinical analysis of 8 cases
10.3760/cma.j.issn.1671-8925.2011.09.018
- VernacularTitle:原发性干燥综合征中枢神经系统损害八例临床分析
- Author:
Ting-Yu YI
1
;
Zong-Zhong WU
;
Yan-Min WU
;
-lai A ZHAN
;
Yue-Hong CHEN
;
Mei-Fang ZHANG
;
Wen-Huo CHEN
Author Information
1. 福建医科大学附属漳州市医院
- Keywords:
Primary Sjogren syndrome;
Central nervous system;
Cranial nerve;
MRI
- From:
Chinese Journal of Neuromedicine
2011;10(9):938-941
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical manifestations, MRI features and therapeutic methods of patients with central nervous system damage secondary to primary Sjogren syndrome.Methods The clinical features, MR1 manifestations and therapeutic method of 8 patients with central nervous system damage secondary to primary Sjogren syndrome, confirmed in our hospital, were retrospectively reviewed and analyzed. Results Wallenberg syndrome, limb weakness and mentality alteration appeared in these patients, some manifested as having multiple sclerosis and neuromyelitis optica, and optic nerve was frequently involved. MRI results indicated that 5 patients had lesion in the spinal cord, mainly located in the cervical and thoracic cords: 2 in the cervical cord, 2 in the thoracic cord, and 1 both in the cervical and thoracic cords; the lesions manifested as sheet lamellar, scattered plaques with mild/obvious enhancement or without enhancement; 5 patients had brain damage: lesious could be detected in the dorsolateral medulla oblongata, thalamus, hippocampus, aqueduct of midbrain,and sides of fourth ventricle and lateral ventricles, and these lesions could manifest as multiple minor ischemic focus white matter in the subcortex and cerebral ventricles, which might be similar to Wernicke encephalopathy; 1 patient appeared cervical artery dissection, and 7 patients got improvement after the treatment of hormone. Conclusion The clinical features and MRI manifestations of patients with central nervous system damage secondary to primary Sjogren syndrome are diverse.
