Association between polymorphisms of transforming growth factor β1 gene and endothelin converting enzyme-1b gene and susceptibility of carotid atherosclerosis
10.3760/cma.j.issn.1671-8925.2011.09.004
- VernacularTitle:转化生长因子β1与内皮素转换酶-1b基因多态性和颈动脉粥样硬化易感性的关联研究
- Author:
Jun FENG
1
;
Xin-Li XIAO
;
Zhe LIU
;
Hao QIN
;
Li-Hua LIU
;
Ming ZHANG
;
Bo ZHANG
;
Ya-Ming LIU
Author Information
1. 西安交通大学医学院附属第一医院
- Keywords:
Atherosclerosis;
Carotid artery;
Transforming growth factor 31;
Endothelin converting enzyme-lb;
Polymorphism,single nucleotide
- From:
Chinese Journal of Neuromedicine
2011;10(9):879-882
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between polymorphisms of transforming growth factor β1 gene and endothelin converting enzyme-1b gene and susceptibility of carotid atherosclerosis. Methods Two hundred and thirty-one patients with carotid atherosclerosis, admitted to and received treatment in our hospital from January 2006 to December 2010, and 231 healthy volunteers were chosen in our study. The polymorphisms of transforming growth factor β1 gene and endothelin converting enzyme-lb gene in these 2 groups were detected with PCR and single nucleotide polymorphism; the differences of these gene and genotype between the 2 groups were compared by statistical analysis.Results The gene and genotype of transforming growth factor β1 gene at rs51695112 locus were significantly different between patient group and control group (x2=6.120, 6.890;P=0.045, 0.033, respectively); the G allele and G/G genotype were risk factors of carotid atherosclerosis susceptibility (OR=1.320, 1.410, respectively). The gene and genotype of endothelin converting enzyme-1b gene at rs32570233 locus were significantly different between the patient group and the control group (x2=6.320, 7.180; P=0.041, 0.022); the A allele and A/A genotype were the risk factors of carotid atherosclerosis susceptibility (OR=1.470, 1.530, respectively). Conclusion There is an association between polymorphisms of transforming growth factor β 1 gene and endothelin converting enzyme-1b gene and carotid atherosclerosis.
