Mannitol combined with continuous hemofiltration in the treatment of intracranial hypertensive patients with renal failure

VernacularTitle:连续血液滤过联合甘露醇治疗颅内高压合并肾功能衰竭的临床研究
Author: Hai-Ting XIE ¹ ; Duo-Bin WU ; Zhong-Li LI ; Ping CHANG ; Zhen-Hua LIU
Author Information

1. 南方医科大学珠江医院
Keywords: Continuous hemofiltration; Mannitol; Intracranial hypertension; Renal failure
From: Chinese Journal of Neuromedicine 2011;10(8):848-850
CountryChina
Language:Chinese
Abstract: Objective To explore the effect of continuous venovenous hemofiltration (CVVH)combined with intravenous injection of mannitol in the treatment of intracranial hypertensive patients with renal failure. Methods Nine intracranial hypertensive patients with renal failure from ICU of our hospital were treated with 2-3 times of CVVH combined with intravenous injection of mannitol; their non-invasive intracranial pressure, serum creatinine and cystatin concentrations before and after the treatments were monitored. Results The difference of intracranial pressure was statistically significant before and after CVVH (P＜0.05), so were the values of serum creatinine and cystatin before and after CVVH (P＜0.05). One patient with brain stem hemorrhage died fiom multiple organ failure 2 d after the treatment, and the other 8 patients all smoothed out the rush hours of brain edema without cerebral hernia.Conclusion CVVH combined with intravenous injection of mannitol is a kind of effective treatment for intraeranial hypertensive patients with renal failure.