Bioinformatic analysis of genes related to tuberous sclerosis complex and refractory epilepsy

VernacularTitle:结节性硬化症与难治性癫痫相关基因的生物信息学分析
Author: Ye ZHOU ¹ ; Yun-Hong YU ; Yong BAO ; Wei XIE ; Chang-Zheng LI
Author Information

1. 南方医科大学
Keywords: Tuberous scleroses complex; Epilepsy; DNA microarray; Bioinformatics
From: Chinese Journal of Neuromedicine 2011;10(8):794-796
CountryChina
Language:Chinese
Abstract: Objective To investigate the genes associated with tuberous scleroses complex and refractory epilepsy with bioinformatics methods to provide new ideas for the basic research and clinical treatment of epilepsy. Methods The microarray data of tuberous scleroses complex and refractory epilepsy were downloaded from the Gene Expression Omnibus (GEO) database and analyzed by bioinformatics methods using String, KEGG and Panther databases.Results Of all the 100 differentially expressed genes, 47 were found to encode proteins with interactions; they involved to multiple biological pathways, biological processes and molecular functions.Conclusion The pathogenesis of tuberous scleroses complex and refractory epilepsy involves multiple genes, such as GFAP, ANXA 2 and S100A 10.