Therapeutic effects of different doses of botulinum toxin A in the treatment of spastic cerebral palsy with different location ways
10.3760/cma.j.issn.1671-8925.2011.06.022
- VernacularTitle:不同定位方式下不同剂量肉毒毒素治疗痉挛性脑瘫的疗效观察
- Author:
Gui-Lan PENG
1
;
Shu-Ying CAI
Author Information
1. 厦门市妇幼保健院
- Keywords:
Cerebral palsy;
Botulinum toxin A;
Location with electromyography;
Stretching hand
- From:
Chinese Journal of Neuromedicine
2011;10(6):630-632
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effects of different doses of botulinum toxin A (BTX-A) and different lacation ways on children with spastic cerebral palsy. Methods One hundred and twenty patients with BTX-A were employed in our study;these patients were performed locations of electromyography (n=60) and reverse stretching hand (n=60), and then, they were equally sub-divided into 6 groups, respectively: receiving injection of BTX-A at doses of 3, 4 and 5 U/kg, respectively (n=20).After injection, they were commenced functional training for 3 months. The gross motor assessment scale (GMFM) was used to assess the motor function of functional areas in these children 3 months after the training. The modified Ashworth scale was used to assess the degree of muscle spasticity. Results The scores of GMFM in patients received treatment with location of electromyography increased as compared with those with reverse stretching hand (P< 0.05), but the scores had no statistically significances among different doses of BTX-A treatment groups (P> 0.05). The Ashwort grade in patients received treatment with location of electromyography alleviated as compared with those with reverse stretching hand (P<0.05), but no statistically significance of grading was noted among different doses of BTX-A treatment groups (P>0.05). Conclusion All parameters in patients received treatment with location of electromyography improve better than those with reverse stretching hand after injection of same dose of BTX-A.
