Expression of human leukocyte antigen gene in 94 patients with cerebral infarction

VernacularTitle:94例缺血性脑卒中患者HLA基因表达分析
Author: Wei CHEN ¹ ; Min LUO ; Hui-Yu FENG ; Hong-Ling WU ; Cheng NG ZHA ; Lu-Lu XIAO
Author Information

1. 广东医学院附属南山医院
Keywords: Cerebral infarction; Human leukocyte antigen; Allele
From: Chinese Journal of Neuromedicine 2011;10(6):618-621
CountryChina
Language:Chinese
Abstract: Objective To discuss the relationship between human leukocyte antigen (HLA) gene heredity and morbidity of cerebral infarction by a random survey on the allele expression of HLA-A, B and DRB1 seats of patients with cerebral infarction. Methods The genotypes of HLA-A, B and DRB1 alleles in 94 patients with cerebral infarction and 122 healthy blood donors were detected by polymerase chain reaction-sequencing based typing (PCR-SBT) method. Results Sixteen alleles in HLA -A locus,32 alleles in HLA -B locus and 25 alleles in HLA -DRB1 locus expressed themselves in these patients with cerebral infarction. The gene frequency of HLA -A*1102 in patients was lower than that in healthy controls, and negative association was found between HLA -A* 1102 allele and cerebral infarction (RR=0.06,P=0.019). Conclusion The research reveals susceptibility association of HLA -A*1102 with patients having cerebral infarction, displaying close genetic immunity correlation between HLA alleles and pathogenesis of cerebral infarction. So, the research in this paper is useful in the clinical prediction of this disease.