Relationship between expressions of mammalian target of rapamycin and vascular endothelial growth factor and pathological grading of meningiomas

VernacularTitle:mTOR、VEGF的表达与脑膜瘤病理分级的关系
Author: Xiao-Hui LI ¹ ; Quan NG HUA ; Zhi LI ; Zhong-Song SHI ; Liang-Cheng ZUO ; An-Qi LUO
Author Information

1. 中山大学附属第一医院
Keywords: Meningioma; Mammalian target of rapamycin; Vascular endothelial growth factor; Pathology
From: Chinese Journal of Neuromedicine 2011;10(6):560-563
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between expressions of mammalian target of rapamycin (mTOR) and vascular endothelial growth factor (VEGF) and pathological grading of meningiomas. Methods Seventy-six specimens of meningiomas, performed resection in our hospital from January 1995 to August 2010, were chosen, in which, 40 were of WHO grade Ⅰ, 24 of WHO grade Ⅱ, and 12 of WHO grade Ⅲ. The expressions of mTOR and VEGF were immunohistochemically studied with SABC method. Results The protein expressions of mTOR and VEGF mainly located in cytoplasm of meningioma cells, and these proteins were granular materials colored from pale yellow to dark yellow. The expressions of mTOR and VEGF were significantly different among meningiomas of grade Ⅰ,Ⅱ and Ⅲ (P<0.05);the expressions of mTOR and VEGF had a positive correlation (r=0.440, P=0.000). Conclusion The expressions of mTOR and VEGF are positively correlated with the tumor grades.