Expressions and correlation of costimulatory molecule B7 -H3 and Ki -67 in human glioma

VernacularTitle:共刺激分子B7-H3和Ki-67在人脑胶质瘤中的表达及相关性
Author: Tao XIN ¹ ; Li-Yong ZHANG ; Li WANG ; Jian-Xin ZHU
Author Information

1. 聊城市人民医院
Keywords: Glioma; B7-H3; Ki-67
From: Chinese Journal of Neuromedicine 2011;10(6):557-559
CountryChina
Language:Chinese
Abstract: Objective To study the expressions of costimulatory molecule B7-H3 and Ki-67 in human glioma and explore their correlation. Methods Forty-six human brain gliomas, collected in our hospital from March 2008 to January 2010, including 21 with low grade and 25 with high grade, were chosen;and 10 normal tissues, collected from patients with cerebral trauma or cerebral hemorrhage at the same period, were chosen. Immunohistochemistry with SABC and SP methods were employed to detect the expressions of B7-H3 and Ki-67. Results B7-H3 and Ki-67 did not express in the normal brain tissues, but their expressions were detected in all glioma tissues of different grades (positive rate of B7-H3: 65.22%, that of Ki-67: 89.13%), which had significant differences (P<0.05). High-grade gliomas showed no significant differences on B7-H3 and Ki-67 expressions as compared with low-grade gliomas (P>0.05);and a positive correlation was noted between B7-H3 and Ki-67 expressions (r=0.417, P=0.014).Conclusion Being the important molecular biological factors, B7-H3 and Ki-67 participate in the development of human glioma and exhibit a synergic effect in this process.