Atorvastatin combined with clopidogrel in preventing carotid artery atherosclerostic plaques of aged patients with infarction
10.3760/cma.j.issn.1671-8925.2011.05.019
- VernacularTitle:阿托伐他汀联合氯吡格雷稳定老年脑梗死患者颈动脉粥样斑块效果分析
- Author:
Yan FENG
1
;
Li-Pin YUAN
;
Chang-Shui XU
;
Jian-Jun MA
;
Xue LI
Author Information
1. 河南省人民医院
- Keywords:
Infarction;
Atherosclerosis;
Atorvastatin;
Clopidogrel
- From:
Chinese Journal of Neuromedicine
2011;10(5):505-508
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effects of atorvastatin combined with clopidogrel on the prevention of carotid artery atherosclerostic plaques in aged patients with infarction. Methods Eighty aged patients with infarction, admitted to out hospital from July 2006 to September 2010, were chosen; these patients were randomly divided into observation group (n=40, giving treatment of atorvastatin combined with clopidogrel) and control group (n=40, giving treatment of treatment of Clopidogrel). The levels of triglyceride (TG), total cholesterol (CH), low-density lipoprotein cholesterol (LDL-C) and lactate dehydrogenase (LDH), the blood viscosity and the platelet maximum aggregation rate (MAR) were measured and the plaque scores were evaluated 4, 12 and 24 w after the treatment.Results As compared with those before treatment, the levels of TG, LDL-C and MAR in the control group 24 w after treatment, and the levels of TG and CH in the observation group 12 w after treatment and the levels of TG, CH, LDL-C and MAR in the observation group 24 w after the treatment were significantly decreased (P<0.05). As compared with the control group, the observation group enjoyed significantly lower level of CH 12w after the treatment and lower levels of TG, CH and LDL-C 24 w after the treatment (P<0.05). Lower plaque scores in the observation group were noted as compared with that in the control group 24 w after the treatment (P<0.05). Conclusion Atorvastatin combined with clopidogrel can safely prevent and stabilize the carotid artery atherosclerostic plaques in aged patients with infarction.
